Rare damaging variants in CHEK2 (OR = 1.69 [1.41–2.01], P = 2.69 × 10−8) and rare synonymous variants in DMD (OR = 0.50 [0.36–0.67], P = 8.6 × 10−7) were associated with prostate cancer risk at the suggestive significance threshold. Here, DMD is linked to prostate cancer.