Beyond BRCA2, of the genes found to be associated with prostate cancer risk, the DDR gene ATM showed the strongest evidence of also being associated with severity (OR = 2.23 [1.47–3.34], P = 9.41 × 10−5, Fig. 2, Supplementary Fig. 8 and Supplementary Data 9). Here, BRCA2 is linked to Familial prostate cancer.