SPDL1 and Familial prostate cancer: SPDL1 is involved in mitotic checkpoint signalling during cell division34, and the SPDL1 missense variant (5:169588475:G:A) protective for prostate cancer in our analysis has previously been shown to increase the risk of idiopathic pulmonary fibrosis (IPF)35, consistent with existing literature on shared genetic alterations between cancer and IPF36.