LONP1 and posterior cortical atrophy: To characterize the roles of LONP1 in the progression of PCa, we established gain- or loss-of-function models involving LONP1 knockdown in PC3 cells and LONP1 overexpression in DU145 cells based on the expression level of LONP1 in PCa cell lines (Fig. 2A, B, Fig. S1A–D).