Contrary to the tumor-preventing effect of Tak1 ablation in KRAS-driven PDAC development, ablation of Rela did not prevent ADM and PDAC formation in KRASG12D mice (KRASG12D RelAΔAc), but instead, it even enhanced tumorigenesis (Supplementary Fig. 2l, m). The gene discussed is KRAS; the disease is neoplasm.