For example, chronic pancreatitis or oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS), which are found in most PDACs3, can induce acinar-to-ductal metaplasia (ADM), a reprogramming process that leads to the dedifferentiation of pancreatic acinar cells and their transdifferentiation into progenitor-like cells with ductal characteristics4. This evidence concerns the gene KRAS and chronic pancreatitis.