The transcription factor Sp1 and the epigenetic regulator UHRF1, which have both been involved in the transcriptional control of RIPK340, are overexpressed in PDAC patient samples and pancreatic cancer cell lines41,42, suggesting that they could also be implicated in the regulation of cell death mediators during transdifferentiation. This evidence concerns the gene UHRF1 and pancreatic neoplasm.