In neurodegenerative diseases, the involvement of CHOP in cell death has also been reported; CHOP KO inhibits amyloid β (Aβ) 1-42-induced neurodegeneration [43] and inhibited Aβ production through suppression of NF-κB binding to the β-site APP-cleaving enzyme 1 promoter [44]. Here, DDIT3 is linked to neurodegenerative disease.