MKI67 and neuroendocrine carcinoma: Regarding OS from first-line treatment start, NEC histology (HR 4.23), high Ki-67 index (HR 3.81), surgery (HR 0.50), ECOG ≥ 1 (HR 11.5), and positive SSTR imaging (HR 0.11) were significant prognosticators in univariate analysis, while NEC histology (HR 2.95) and ECOG ≥ 1 (HR 11.5) remained statistically significant in multivariable analysis, see Table 2.