Currently recognized prognostic factors for NEC include primary site, small-cell morphology, Ki-67 index, metastatic disease, elevated lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels, and performance status (Sorbye et al. 2023; Lamarca et al. 2017). The gene discussed is MKI67; the disease is neuroendocrine carcinoma.