The results of multivariable analysis revealed that AFP (hazard ratio (HR) = 2.60, 95% confidence interval (CI) = 1.09–6.19, p = 0.031), portal hypertension (HR = 2.27, 95% CI = 1.06–4.86, p = 0.035), tumor number (HR = 1.85, 95% CI = 1.05–3.24, p = 0.033), and tumor diameter (HR = 1.84, 95% CI = 1.01–3.36, p = 0.047) were independent prognostic factors for LTP. The gene discussed is AFP; the disease is portal hypertension.