GLI1 and neoplasm: Results showed a significant decrease in EGFR, CBP, and SMARCB1 at mRNA and protein levels, and a significant increase in mRNA of EZH2, but no significant change in protein levels for EZH2, suggesting that both MEOX2/GLI-1 modulate these tumor and epigenetic markers in lung cancer A549 cells (Fig. 1A).