Overall, these epigenetic fluctuations suggest that MEOX2 and GLI-1 are functionally involved in transcriptional and epigenetic regulation of the EGFR oncogene expression in a Polycomb versus Trithorax dependent manner in solid lung tumors in vivo, highlighting an increased SMARCB1 occupancy on EGFR genetic sequences through the use of shMEOX2, suggesting the involvement of MEOX2 in SMARCB1 expression and its role in lung cancer progression. Here, MEOX2 is linked to lung cancer.