In order of smallest Padj, the KEGG pathways enriched were ‘circadian entertainment’, ‘nicotine addiction’, ‘asthma’, ‘neuroactive ligand-receptor interaction’, ‘cAMP signalling pathway’, ‘cholinergic synapse’, ‘glutamatergic synapse’, ‘systemic lupus erythematosus’, ‘intestinal immune network for IgA production’, and ‘Th1 and Th2 cell differentiation’ (Fig. 3A). The gene discussed is CD79A; the disease is nicotine dependence.