LEP and neoplasm: To further validate the protective effects of SIRT6 on tumour‐induced lipolysis, we first derived mouse embryonic fibroblasts (MEFs) from SIRT6 KO, SIRT6 WT or SIRT6 TG mice and differentiated them into mature adipocytes (verified by significantly increased expression of mature adipocyte markers including adiponectin, ASC1 and leptin, Figure S4A) [27], before treating them with LLC cell‐conditioned medium (LLC‐CM).