SIRT6 overexpression significantly ameliorated tumour‐induced wasting and energy expenditure in white adipose tissues (eWAT mass loss: 66% in WT vs. 32% in TG; iWAT mass loss: 69% in WT vs. 40% in TG) through suppression of browning and lipolysis. The gene discussed is SIRT6; the disease is neoplasm.