Using the alternative definition of ‘advanced HIV’ as CD4+T cell count <100/mm3, the observed three deaths are compatible with 11 cases (95% CI 8 to 17) among MSMLAHIV in South Africa, which would imply that case ascertainment among MSMLAHIV has been extremely high, with 99.4% (95% CI 90.4% to 100%) of infections in this group already observed. This evidence concerns the gene CD4 and infection.