BH has been shown to increase M1 macrophage-associated markers (e.g., IFN-γ, CD68, IL-6, MMP9, and IL-1β) and decrease M2 macrophage markers (e.g., CD163, IL-10, and CD200R1), as determined by gene expression levels following in vitro treatment of 3D BC spheroids (59). Here, IFNG is linked to breast cancer.