After the second 6-month period in which FMD->Control participants returned to their dietary habits (T2), compared to T1 values, no significant (p > 0.01) differences were found in leptin, IGF-1, ghrelin, serum glucose, insulin, total cholesterol, LDL, HDL, TGs, ESR, CRP, conjugated and unconjugated bilirubin, AST, ALT, uremia and serum creatinine, HOMA %B, HOMA %S, HOMA-IR, WC, weight, BMI, and VF level. This evidence concerns the gene LEP and uremia.