When comparing Control->FMD (n = 38) after 6 FMD cycles following the cross-over (T2 vs. T1), we observed a significant (p < 0.01) decrease in leptin, IGF-1, serum glucose, insulin, total cholesterol, LDL, AST, ALT and uremia, HOMA-IR, as well as in WC, BMI, estimated FM (in both % and kg), and VF levels, whereas a significant (p < 0.01) increase was found in ghrelin, HDL, HOMA %S, and estimated MM (in both % and kg, respectively). This evidence concerns the gene IGF1 and uremia.