CALCR and melanoma: As the glycolytic phenotype of cells often leads to acidification of the tumor microenvironment [68], which may promote the transport of copper ions into the cell due to the intensified activity of CTR1 in response to reduced extracellular pH [76], the BRAFV600E-MITF-PGC1α regulatory mechanism of the glycolytic phenotype of melanoma cells can contribute to a broader effect on the cell phenotype because of enhanced copper influx.