LINC02747 and hydrops fetalis: The result of the calcium upregulationby percutaneous administration of gene therapy in patients with cardiacdisease (CUPID) trial was published in 2016 as the largest gene transferstudy for the treatment of HF.38 CUPID2 was a phase 2b trial using AAV1 vector encoding sarcoplasmic/endoplasmicreticulum Ca2+-ATPase (SERCA2a) for HF patients via anterogradecoronary infusion.