Interestingly as found in the studies by Calvani et al. (2013) and Joseph et al. (2016), older humans with sarcopenia have similar contents of endogenous antioxidants like superoxide dismutase, catalase, and glutathione peroxidase which parallels with the findings in ageing mice with whole-body overexpression of catalase in the mitochondria, compared to younger individuals, suggesting that more endogenous antioxidant activity is necessary to combat the age-associated increase in ROS production. The gene discussed is CAT; the disease is sarcopenia.