According to Teach et al. (2015), aeroallergens were suggested to be more predictive for childhood asthma exacerbation, within the city during the fall season (compared to other seasons — i.e., spring, summer, winter) — as indicated by a higher portion of variance from the models explained by serum IgE levels (Teach et al. 2015). This evidence concerns the gene IGHE and asthma.