Other research found that class II molecules (HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5) are important biomarkers in the occurrence and progression of melanoma tumors, and their expression levels are closely related to prognosis and immune infiltration [58]. This evidence concerns the gene HLA-DRB5 and melanoma.