Additionally, both Parp7−/− and Parp7H532A/H532A mice had significantly higher levels of IgM and IgA, but not IgG, autoantibodies against a wide range of antigens commonly associated with lupus and other autoimmune diseases (Fig. 4, C and D; and Fig. S2, C–H). Here, TIPARP is linked to systemic lupus erythematosus.