TIPARP and autoimmune disease: Additionally, we found that Parp7−/− and Parp7H532A/H532A mice had significantly elevated levels of serum IgA anti-PL-7 (Fig. 5 H), which is associated with an autoimmune disease called Antisynthetase syndrome, and patients with anti-PL-7 autoantibodies frequently develop severe idiopathic lung disease (Witt et al., 2016).