After correcting for age, hypertension history, CAD history, smoking history, FBG, TC and LDL, the risk for high-grade ARAS was decreased from the first tertile of eGFR to the third tertileof eGFR(OR = 0.261, 95% CI: 0.080–0.852, P = .026); the risk for high-grade ARAS was increased from the first tertile of cystatin C to third tertile of cystatin C (OR = 4.635, 95% CI: 1.345–15.975, P = .015). This evidence concerns the gene CST3 and Hypertension.