After adjusting for potential confounding factors, such as age, hypertension history, CAD history, smoking history, FBG, TC and LDL, which is referred to as model II, eGFR (OR = 0.979, 95% CI: 0.962–0.996, P = .017), cystatin C (OR = 2.123, 95% CI: 1.118–4.030, P = .021) and LMR (OR = 0.639, 95% CI: 0.421–0.969, P = .035) were still correlated with high-grade ARAS. The gene discussed is CST3; the disease is coronary artery disorder.