Therefore, a proposed approach involves the combination of biomarkers with severity scores to enhance predictive outcomes.[29,30] Subsequently, we combined the biomarker G-CSF with SOFA and G-CSF together with APACHE II and found that G-CSF + SOFA and G-CSF + APACHE II showed better discrimination (AUC1 = 0.874, sensitivity 73.8%, and specificity 89.8%; AUC2 = 0.791, sensitivity 68.9%, and specificity 85.7%) for predicting the prognosis of patients with sepsis than G-CSF alone. Here, CSF3 is linked to Sepsis.