VWF and systemic lupus erythematosus: However, studies have found no cases of severe ADAMTS-13 deficiency (<5%) in SLE patients, with the lowest recorded being 13%, and a negative correlation with significantly increased vWF levels.[7] Therefore, the patient’s ADAMTS-13 activity test results do not match previously reported SLE-TTP cases, further suggesting that the TTP in this patient is more likely related to the recent SARS-CoV-2 infection rather than an exacerbation of SLE.