Song Chunhong, Wang Jieqiong et al[78] find the effects of peony extract on the hypothalamic signaling pathway in rats with liver-qi depression syndrome, which can inhibit the calmodulin/Ca2+/calmodulin-dependent protein kinase II (CaM/CaMK II) signaling pathway mediated by Voltage-dependent L-type calcium channel subunit alpha-1C(Cav1.2), provide protection to the nervous system, and treat mental disorders related to emotional disorders. Here, CACNA1C is linked to psychiatric disorder.