At the same time, it can also treat kidney disease caused by spleen kidney Yang deficiency, improve edema, and delay renal function damage.[79] Experimental evidence has shown that paeoniflorin can regulate the phosphatidylinositol 3-kinase(PI3K)/AKT/MTOR signaling pathway, significantly increasing the levels of 5-HT and NE in hippocampal and cortical tissues.[80] Other studies have shown that[81] paeoniflorin can reduce the phosphorylation levels of PI3K, AKT, and MTOR, inhibit the activation of the PI3K/AKT/MTOR signaling pathway, and in some cases, lower blood pressure. This evidence concerns the gene AKT1 and kidney disorder.