ESR1 and premenstrual tension: For example, it upregulates the level of monoamine neurotransmitters, regulates the function of the hypothalamic-pituitary-adrenal axis(HPA axis), and upregulates estrogen receptor (ER) expression.[7] However, at present, the pathogenesis of PMS has not been fully understood, and the specific molecular mechanism of CSS compound has not been systematically elucidated.