HTT and Huntington disease: Huntington disease (HD) is a genetic neurodegenerative disorder characterized by progressive neuronal degeneration in the brain.[1] The etiology of this illness can be attributed to a genetic mutation that results in the synthesis of an atypical variant of the huntingtin protein.[2] It manifests with various motor, cognitive, and mental symptoms.[3] The pathogenesis of HD is characterized by the progressive deterioration of specific regions of the brain, especially the striatum.