In conclusion, this study used network pharmacology and computer simulation of molecular docking to demonstrate that the active ingredients of Polygonatum, such as beta-sitosterol, baicalein, and liquiritigenin, exert their therapeutic efficacy in treating Alzheimer’s disease by acting on targets such as AKT1, TP53, CASP3, JUN, STAT3, and others. This evidence concerns the gene CASP3 and Alzheimer disease.