AKT1 and Alzheimer disease: It serves as a crucial target of the PI3K-Akt signaling pathway, which regulates cell division, proliferation, apoptosis, and glucose metabolism.[79] Abnormal brain insulin metabolism has long been considered a pathogenic mechanism of AD and has been experimentally demonstrated.[80] AKT1 activation is not only related to learning and memory,[81–83] but also normalizes insulin signaling.