STAT3 and early-onset autosomal dominant Alzheimer disease: Activation of STAT3 was found to be effective in rescuing hTau-induced synaptic dysfunction and memory impairment in mice in animal experiments.[85] However, specific knockdown of STAT3 in AD model mice significantly reduced their brain amyloid levels and plaque load.[86] This suggests that the role of STAT3 in Alzheimer’s disease is 2-fold.