ACHE and Alzheimer disease: This suggests that 4′,5-dihydroxyflavone may have neuroprotective effects through dopaminergic synaptic pathways.[69] Among the available treatments for Alzheimer’s disease are acetylcholinesterase inhibitors, such as donepezil, galantamine, and others, which have been approved for use in treating mild, moderate, and severe cases of Alzheimer’s disease.