CD8A and neoplasm: Research indicates that the CD8-expressing, CD1-independent NKT cell subset is designated as CD8+ NKT cells.[34] CD8+ NKT cells produce a spectrum of cytokines, such as high levels of interferon-γ, and demonstrate potent tumoricidal activity against tumor cells.[35–37] Furthermore, the CD8+ NKT cells suppress the immune response in an antigen-specific manner by effectively killing antigen-bearing DCs.[38] Elevated serum TG levels increase the risk of LMS, which is largely mediated by CD8+ NKT cells.