According to KEGG pathway analysis, 173 signaling pathways are expressed during the DVT process (Table S8, Supplemental Digital Content, http://links.lww.com/MD/O240), Furthermore, screening revealed that these pathways were primarily implicated in the VEGF signaling route, FoxO signaling pathway, HIF-1 signaling pathway, and Jak-STAT signaling pathway (Fig. 5D). Here, HIF1A is linked to deep vein thrombosis.