IFNG and neoplasm: Th1 and cytotoxic T cells release interferon-gamma (IFN-γ), which prevents tumor angiogenesis by restricting the growth of endothelial cells, while helper T cell 2 (Th2) encourages the differentiation of tumor-infiltrating monocytes and macrophages into pro-angiogenic tumor-associated macrophages (TAMs).[39] Experimentally, Similar to wound healing, thrombus regression begins with neutrophil-driven effects and progresses to fibrinolysis, neovascularization, and collagen replacement mediated by monocytes and macrophages.