Of all parameters, age, history of allergies, clinical symptoms (including sore throat, hoarseness, wheezing, barking cough, dyspnea, diffuse congestion, swelling of the laryngeal mucosa, vocal cord congestion), laboratory indicators (WBC count, and CRP, TNF-α, IL-4, IL-6, IL-17, and IFN-γ levels) were risk factors for the efficacy of treatment in children with acute laryngitis and laryngeal obstruction (Table 3). This evidence concerns the gene TNF and allergic disease.