KCNJ2 and major depressive disorder: Therefore, the neurological or neurocognitive symptoms of patients with KCNJ2 gene mutation, including mild learning difficulties, problems with memory or concentration, psychological problems, and depression would be conceivable.[1] Here, we report a young boy with LQT7 and a learning disability due to a de novo missense mutation in the KCNJ2 gene (c.224 C > A, p.Thr75Lys).