GLP1R and diabetes mellitus: According to Park JK, et al, there were significant improvements in FBG, HbA1c, inflammatory markers (e.g., interleukin-6, cyclooxygenase-2, and C-reactive protein) following a 12-week treatment with RGEP100 mg/kg in db/db mice.[39] Kang KS, et al showed that Rg3 was effective in protecting against diabetes by inhibiting oxidative stress in a streptozotocin-induced diabetic renal damage model.[40] Finally, Rg3 had an antihyperglycemic effect by up-regulating GLP-1 via the sweet taste receptor-mediated signal transduction pathway in db/db mice.[41]