Furthermore, the impact of important pathological factors, proteins (NLRP3, ASC, caspase‐1, IL‐1B, IL‐18, IL‐1RA, IL‐18BP) and IL‐18/IL‐18BP cytokine ratio on survival in IPMN and PDAC was investigated. This evidence concerns the gene IL18 and pancreatic intraductal papillary-mucinous neoplasm.