While the nucleotide‐binding oligomerization domain (NOD)‐like receptor pyrin domain containing 3 (NLRP3) inflammasome pathway's role in pancreatic ductal adenocarcinoma (PDAC) has been extensively studied, its implications in IPMN remain unexplored. The gene discussed is NLRP3; the disease is pancreatic intraductal papillary-mucinous neoplasm.