Expression levels of NLRP3, apoptosis‐associated speck‐like protein containing a caspase‐recruitment domain (ASC), caspase‐1, interleukin‐1 beta, interleukin‐18 (IL‐18), interleukin‐1 receptor antagonist, and interleukin‐18 binding protein (IL‐18BP) were evaluated and compared between IPMN and PDAC samples. The gene discussed is NLRP3; the disease is pancreatic intraductal papillary-mucinous neoplasm.