Therefore, this study investigated the protein expression of NLRP3, ASC, caspase‐1, IL‐1B, IL‐18, IL‐1RA, and IL‐18BP on tumor cells by utilizing multiplexed immunohistochemistry on PDAC and IPMN samples, examining their association with pathological features and prognoses. Here, IL18 is linked to pancreatic intraductal papillary-mucinous neoplasm.