We used Cox proportional hazard modeling and Kaplan–Meier analysis to evaluate the impact of pathological prognostic factors and specific proteins, including NLRP3, ASC, caspase‐1, IL‐1B, IL‐18, IL‐1RA, IL‐18BP, as well as the IL‐18/IL‐18BP ratios, on survival of patients with IPMN and PDAC. This evidence concerns the gene IL18BP and pancreatic intraductal papillary-mucinous neoplasm.