Furthermore, the release of pro‐inflammatory cytokines derived by NLRP3 activation can activate inflammatory cancer‐associated fibroblasts, which event could contribute to the formation of desmoplastic stroma, enhance tumor cell survival, promote resistance to chemotherapy, and create an immunosuppressive microenvironment in pancreatic cancer [14, 15]. This evidence concerns the gene NLRP3 and pancreatic neoplasm.