Moreover, ac4C modifications mediated by NAT10 have been implicated in the initiation and advancement of diverse cancers by influencing mRNA stability, translation efficiency, and DNA repair processes, potentially unveiling new mechanisms and therapeutic targets for cancer therapy (Boo and Kim, 2020; Cui et al., 2022; Jin et al., 2020; Liu et al., 2024b; Wang et al., 2023a). The gene discussed is NAT10; the disease is cancer.