Difficult clostridium persist in such organs and produce the TcdA and TcdB, lower on DRA (downregulated in adenoma, Cl−/[Formula: see text] exchanger) [73] and inhibition of the Na(+)/H(+) exchanger 3 (NHE3) [71] altering the gut environment and the composition of the microbiome. Here, SLC9A3 is linked to adenoma.