E3 ubiquitin ligases, such as the F‐box and WD40 repeat domain containing‐7 (Fbxw7) and β‐TrCP destabilize YAP1 by targeting it for ubiquitination and proteasomal degradation in hepatocellular carcinoma (HCC) and pancreatic cancer.18, 19, 20. This evidence concerns the gene BTRC and hepatocellular carcinoma.