Titin+ patients had increased risk of hypertension [OR = 2.358 (95% CI 1.606, 3.463)], diabetes [OR = 1.882 (95% CI 1.171, 3.026)], cardiovascular and cerebrovascular diseases [OR = 1.976 (95% CI 1.173, 3.330)], and eye diseases [OR = 3.800 (95% CI 1.573, 9.181)]. The gene discussed is TTN; the disease is cerebrovascular disorder.