According to the Endocrine Society Clinical Practice Guideline, the patient should undergo further workup for hypoglycemia if it is confirmed by the presence of Whipple’s triad (symptoms of hypoglycemia in the setting of low glucose level, at least below 55 mg/dL, and resolution of symptoms after glucose intake) [12]. The second step is the determination of insulin and C-peptide levels. The gene discussed is INS; the disease is Hypoglycemia.