This dual-faceted role of NO is highlighted by its vascular protective functions courtesy of endothelial NOS (eNOS)-derived NO, juxtaposed against the noxious sequel of inducible NOS (iNOS) over-expression under chronic inflammatory stimuli, commonly witnessed in PCOS phenotypes characterized by insulin resistance (11) (Figure 1). The gene discussed is NOS3; the disease is polycystic ovary syndrome.