IGF1 and acromegaly: Acromegaly (clinically since age 48 y, IGF-1 +5.7 SD, unsuppressed GH in OGTT). NF1 (diagnosis at age 58 y). History of bladder PGL and retroperitoneal fibrosis (54 y), abdominal aneurysm (61 y), FTC, and PHPT (one adenoma), Treated with lanreotide and then TSS. FH of NF1