TLR9 and Sepsis: However, evidence that CLP performed in the active phase (ZT19) led to higher mortality compared to the inactive phase (ZT7) in 6-12-week-old C57BL/6 TLR9−/- mice (80 vs. 30%, mixed sex) suggests that TLR9 is not involved in the circadian dependency of sepsis mortality per se (52).