Pathological settings, notably hypotension early in clinical and endotoxin-induced septic shock, increase AVP to supra-physiological levels (20- to 200-fold increase) in human, dog, and baboon plasma (81, 82), however, sepsis in C57BL/6 mice following CLP produced only a mild 4% increase in plasma AVP after 12 hours compared to sham mice (83). This evidence concerns the gene AVP and Sepsis.