Leptin levels increase in patients with sepsis and murine sepsis models in association with increased pro- and anti-inflammatory cytokines, including IL-6 and IL-10 (62, 70, 136–138), while in patients, this occurs concurrent with a loss of circadian rhythm (62); whether leptin rhythmicity changes in murine models of sepsis is currently unknown. The gene discussed is LEP; the disease is Sepsis.