Obesity has been related to the chronic activation of proinflammatory signaling pathways, in which the NFκB is a critical component that controls the transcription and release of downstream pro‐inflammatory cytokines, such as IL‐6, TNF‐α, and IL‐1β (Nisr et al. 2019). The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.