Obesity has been related to the chronic activation of proinflammatory signaling pathways, in which the NFκB is a critical component that controls the transcription and release of downstream pro‐inflammatory cytokines, such as IL‐6, TNF‐α, and IL‐1β (Nisr et al. 2019). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.