In addition, techniques for measuring other isotypes such as pan-IgG, IgG4, and IgG3 are already playing significant roles in understanding; the response to immunotherapy, Eosinophilic esophagitis, and the possible chronic effects of exposure to the oligosaccharide alpha-gal in the diet of patients with specific IgE antibodies. The gene discussed is IGHE; the disease is eosinophilic esophagitis.