Interestingly, both changes in food behaviors under challenging HFD and glucose intolerance were also described for Gal-KO mice (Ahrén et al., 2004; Adams et al., 2008), suggesting the role of galanin and GalR1 in adjusting food intake and metabolic responses to variations in dietary fat while also influencing glucose regulation in mice (Zorrilla et al., 2007). This evidence concerns the gene GAL and Glucose intolerance.