SREBF1 and diabetes mellitus: FXR controls lipid metabolism by repression of sterol regulatory element-binding protein 1c (SREBP-1c) in liver (63), and in mouse models of streptozotocin induced diabetes and diet induced obesity, SREBP-1 was shown to be overabundant in the kidney where it promoted renal lipid accumulation and the expression of profibrotic factors which all contribute to kidney damage (64).