SERPINF1 and chronic kidney disease: Serpin family F member 1 (SERPINF1) is a member of the serine protease inhibitor family with antiangiogenic, antioxidative, anti-inflammatory, antitumorigenic, and renoprotective activity (41) It was upregulated (log2 fold change = 0.12) in cats with CKD correlating with human data in which SERPINF1 has been shown to increase in later stages of CKD (42).