Of the 8 DAPs common to the three major groupings of disease severity (Table 3), four [adaptor related protein complex 3 subunit delta 1 (AP3D1); golgi SNAP receptor complex member 2 (GORS2); keratin 77 (KRT77); and nucleolus and neural progenitor protein (C3orf17)] have not been described as being associated with pain or osteoarthritis (OA) in the literature. This evidence concerns the gene GOSR2 and osteoarthritis.