APP and Alzheimer disease: Many of these abnormal sleep phenotypes, such as sleep fragmentation and reduced NREM sleep amount and intensity, have been replicated in mouse models of AD that include APP/PS1, 3xTg-AD, Tg2576, J20, APP23, and 5xFAD mice (Sethi et al., 2015, Kent et al., 2018, Van Erum et al., 2019, Filon et al., 2020, Drew et al., 2023).