In this study, infection of RAW264.7 cells with PCV2 at a titer of 104.5 TCID50/0.1 mL for 12 and 24 h resulted in a significant increase of the levels of IL-6, IL-8, IL-10, MCP-1, TNF-α, ROS, and NO. The gene discussed is CXCL8; the disease is infection.