In this study, we examined whether MEL inhibits EMT and the production of ECM by modulating the TGF-β1/Smad2/3 pathway, improves mitochondrial function, and reduces OS through the activation of the AMPK/SIRT1/PGC-1α signaling pathway, thereby ameliorating BLM-induced PF in mice. This evidence concerns the gene TGFB1 and Bloom syndrome.