As an upregulated lncRNA in ovarian cancer tissues and cell lines, HOTTIP silencing leads to NLRP1 inflammasome-mediated pyroptosis, decreases cell viability, increases the expression of pro-pyroptosis factors, like IL-18, IL-1β, and NLRP1, and activates caspase-1 in ovarian cancer cells. This evidence concerns the gene NLRP1 and ovarian cancer.