Whereas the role of YTHDF2 and m6A erasers FTO and ALKBH5 in hepatocellular carcinoma remains unclear or different mechanisms exist to promote and suppress tumors (Chen et al., 2022[30], 2024[15]; Zhong et al., 2019[360]; Liao et al., 2023[142]; Liu et al., 2022[152]; Wang et al., 2023[271]). The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.