METTL3 and cancer: METTL3 plays a pro-carcinogenic role in most malignant tumors (Cheng et al., 2024[33]; Bhattarai et al., 2024[6]; Vaid et al., 2024[239]), but also acts as a cancer suppressor in certain tumors (Chen et al., 2024[26]; Zhang et al., 2024[335]).