Although the proportions of different immune cell subsets infiltrating CT26 tumors vary among studies, Mosely and colleagues defined the CT26 tumor model as immunoinflammatory, characterized by high infiltration of natural killer (NK) (>26%) and T cells (>18%), among which CD8+ cytotoxic T lymphocytes (CTLs) are predominant (>5%).39 This evidence concerns the gene CD8A and neoplasm.