In contrast, the most downregulated KEGG pathways were related to Protein Signaling and Cell Death and Survival (EIF2 Signaling) (negative Z score and −log(p value) = 3.1), followed by BEX2 Signaling Pathway (−log(p value) = 3) and Developmental Disorder and Metabolic Disease (Oxidative Phosphorylation) (−log(p value) = 1.7) (Figure 4A). Here, BEX2 is linked to Other metabolic disease.