MKT-077: This compound is a mitochondrial-targeted inhibitor of HSP70 and selectively induces apoptosis in cancer cells. Its mechanism involves destabilizing mitochondrial function, which leads to cell death in cells that rely heavily on HSP70 for survival, such as many cancer types. YM-01 and YM-08: inhibit HSP70 by impairing its ATPase activity, thus disrupting protein folding. They have shown promise in studies targeting tumor cells. This evidence concerns the gene DNAH8 and cancer.