Within the context of AD, HSP70 proteins exhibit safeguarding functions through several pathways, such as inhibiting Aβ oligomer formation (Evans et al., 2006), transitioning Aβ into a structure less prone to amyloidogenesis, enhancing the breakdown of Aβ by specific enzymes, and reestablishing tau equilibrium by promoting the clearance of phosphorylated tau aggregates, likely via the ubiquitin-proteasome and/or autophagy pathways (Moyano et al., 2021; Batko et al., 2024). Here, MAPT is linked to Alzheimer disease.