For instance, tau hyperphosphorylated on threonine 181 is found in blood, which optimize its use as an easy-to-collect biomarker in AD diagnosis (Thijssen et al., 2020), whereas the deficiency of super oxide dismutase 2 (SOD2) exacerbate the levels of tau hyperphosphorylated on serine 396 in mice (Flynn and Melov, 2013; Melov et al., 2007). The gene discussed is MAPT; the disease is Alzheimer disease.